As an orthopedic surgeon, I always look forward to the announcements of the Nobel Prize winners each year. It is a time I reflect on the decades of dedication that contributed to scientific advancement. This year, I was thrilled to learn that Victor Ambros, PhD, the Silverman Chair in Natural Sciences and professor of molecular medicine at UMass Chan Medical School will share the 2024 Nobel Prize in Physiology or Medicine for his co-discovery of microRNA.
Victor and his longtime collaborator, Gary Ruvkun, PhD, received the Nobel Prize in Medicine for their groundbreaking discovery of microRNA, a pivotal molecule that helps decode our DNA. Victor co-authored the seminal paper with his wife Candy, and it is a fascinating read.
MicroRNA Breakthrough
For those who have never heard of microRNA and to put it into perspective, here is how I would explain it as a simple orthopedic surgeon:
“Imagine you have a blueprint for a pre-planned city. There are hundreds of general contractors copying the information from blueprints and going about ordering the equipment and materials. The subs are feverishly working on their deadlines. Steel support beams are crucial, so it’s important to have those orders as a top priority. How would the message, “we have enough steel support beams, don’t order anymore,” get through? Introduce a foreman who crosses out that part of the plan, checking it off as complete so to speak. This is how microRNA does its magic.”
Although I don’t know Victor and Candy well, my connection runs deep through my brother, H. Scott Silverman, who worked in Victor’s lab during college and completed his honors thesis under Victor’s mentorship. My brother often shared inspiring stories about his experience, highlighting Victor’s passion and dedication to advancing our understanding of the world around us.
Victor’s humble words resonate deeply: “Scientific inquiry uncovers surprises that lead to new principles and discoveries.” This spirit of curiosity and mentorship has not only influenced many aspiring scientists, it also motivated my family to support Victor’s work through the Silverman Chair in Natural Sciences.
Congratulations, Victor, on this ultimate recognition of your remarkable contributions!
You can read more about Victor, his work with MicroRNA and how he learned he had won the Nobel Prize by following the links!